Comparing the Metal Concentration in the Nails of Healthy and Cancer Patients Living in the Malwa Region of Punjab, India with a Random European Group – A Follow up Study. British Journal of Medicine and Medical Research, 2015; Vol. 5, Issue 4
Conclusión: Los fertilizantes de agua, suelo y fosfato parecen juegan un papel potencial, provocando un aumento de metal carga en Punjabi personas que viven en Malwa región. La alta concentración de varios elementos potencialmente tóxicos que se encuentran en el cabello y las uñas reflejan una alta carga de metal tóxico. Tóxico metales como Pb o U provocan estrés oxidativo y daño del ADN [115], por lo tanto, exposición a largo plazo a múltiples elementos tóxicos debe considerarse un posible causa del aumento de la región de Malwa tasa de cáncer.
D. J. HUNTER1,2, J. S. MORRIS3, C. G. CHUTE2, E. KUSHNER1, G. A. COLDITZ1, M. J. STAMPFER1,2, F. E. SPEIZER1 and W. C. WILLETT1,2,4
To assess the validity of the selenium concentration in human toenails as a measure of selenium intake and to determine other correlates of toenail selenium level, the authors examined toenail selenium within two subgroups of a large cohort study of US women. Mean toenail selenium was higher among 38 consumers of selenium supplements (0.904 µg/g, standard deviation (SD) 0.217) than among 96 nonusers (0.748 µg/g, SD 0.149; p<0.001), and a dose-response relation was observed among supplement users (Spearman's r=0.32; p=0.05). In a second subgroup of 677 women, selenium supplement use was also associated with higher mean toenail selenium (0.906 µg/g, SD 0.214, among 18 users and 0.801 µg/g, SD 0.148, among 659 nonusers; p=0.02), and the dose-response relation was also significant (Spearman's r=0.50; p=0.03). The geographic variation in toenail selenium levels was consistent with the geographic distribution of selenium in forage crops. Toenail selenium declined with age and was significantly reduced among cigarette smokers (mean=0.746, SD 0.124, among 146 current smokers and mean=0.817, SD 0.159, among 311 never smokers; p<0.001) but was not materially affected by alcohol consumption.
Conclusion:
These data provide further evidence for the validity of toenail selenium as a measure of selenium intake and indicate the need to control for age and cigarette smoking in epidemiologic studies of the health effects of selenium exposure.